Impact of panel design and cut-off on tumour mutational burden assessment in metastatic solid tumour samples

Tumour mutational burden (TMB) has emerged as a promising biomarker to predict immune checkpoint inhibitors (ICIs) response in advanced solid cancers. However, harmonisation of TMB reporting by targeted gene panels is lacking, especially in metastatic tumour samples. To address this issue, we used d...

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Bibliografische gegevens
Gepubliceerd in:Br J Cancer
Hoofdauteurs: Mankor, Joanne M., Paats, Marthe S., Groenendijk, Floris H., Roepman, Paul, Dinjens, Winand N. M., Dubbink, Hendrikus J., Sleijfer, Stefan, Cuppen, Edwin, Lolkema, Martijn P. J. K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2020
Onderwerpen:
Brief Communication
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7109082/
https://ncbi.nlm.nih.gov/pubmed/32094484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-020-0762-5
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