MGMT promoter hypermethylation is a frequent, early, and consistent event in astrocytoma progression, and not correlated with TP53 mutation

Hypermethylation of the MGMT gene promoter and mutation of the TP53 tumor-suppressor gene are frequently present in diffuse astrocytomas. However, there is only anecdotal information about MGMT methylation status and TP53 mutations during progression of low-grade diffuse astrocytoma (AII) to anaplas...

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Main Authors: Groenendijk, Floris H., Taal, Walter, Dubbink, Hendrikus J., Haarloo, Cathleen R., Kouwenhoven, Mathilde C., van den Bent, Martin J., Kros, Johan M., Dinjens, Winand N. M.
Format: Artigo
Jezik:Inglês
Izdano: Springer US 2010
Teme:
Laboratory Investigation - Human/Animal Tissue
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024495/
https://ncbi.nlm.nih.gov/pubmed/20593220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-010-0274-x
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