Inhibiting the coregulator CoREST impairs Foxp3(+) Treg function and promotes antitumor immunity

Foxp3(+) Tregs are key to immune homeostasis, but the contributions of various large, multiprotein complexes that regulate gene expression remain unexplored. We analyzed the role in Tregs of the evolutionarily conserved CoREST complex, consisting of a scaffolding protein, Rcor1 or Rcor2, plus Hdac1...

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Bibliografiska uppgifter
I publikationen:J Clin Invest
Huvudupphovsmän: Xiong, Yan, Wang, Liqing, Di Giorgio, Eros, Akimova, Tatiana, Beier, Ulf H., Han, Rongxiang, Trevisanut, Matteo, Kalin, Jay H., Cole, Philip A., Hancock, Wayne W.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2020
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7108912/
https://ncbi.nlm.nih.gov/pubmed/31917688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI131375
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