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Inhibiting the coregulator CoREST impairs Foxp3(+) Treg function and promotes antitumor immunity
Foxp3(+) Tregs are key to immune homeostasis, but the contributions of various large, multiprotein complexes that regulate gene expression remain unexplored. We analyzed the role in Tregs of the evolutionarily conserved CoREST complex, consisting of a scaffolding protein, Rcor1 or Rcor2, plus Hdac1...
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| Publicado no: | J Clin Invest |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7108912/ https://ncbi.nlm.nih.gov/pubmed/31917688 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI131375 |
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