Visceral adipose NLRP3 impairs cognition in obesity via IL-1R1 on CX3CR1(+) cells

Induction of the inflammasome protein cryopyrin (NLRP3) in visceral adipose tissue (VAT) promotes release of the proinflammatory cytokine IL-1β in obesity. Although this mechanism contributes to peripheral metabolic dysfunction, effects on the brain remain unexplored. We investigated whether viscera...

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Bibliografiska uppgifter
I publikationen:J Clin Invest
Huvudupphovsmän: Guo, De-Huang, Yamamoto, Masaki, Hernandez, Caterina M., Khodadadi, Hesam, Baban, Babak, Stranahan, Alexis M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2020
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7108893/
https://ncbi.nlm.nih.gov/pubmed/31935195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI126078
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