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Visceral adipose NLRP3 impairs cognition in obesity via IL-1R1 on CX3CR1(+) cells

Induction of the inflammasome protein cryopyrin (NLRP3) in visceral adipose tissue (VAT) promotes release of the proinflammatory cytokine IL-1β in obesity. Although this mechanism contributes to peripheral metabolic dysfunction, effects on the brain remain unexplored. We investigated whether viscera...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Guo, De-Huang, Yamamoto, Masaki, Hernandez, Caterina M., Khodadadi, Hesam, Baban, Babak, Stranahan, Alexis M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7108893/
https://ncbi.nlm.nih.gov/pubmed/31935195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI126078
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