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Visceral adipose NLRP3 impairs cognition in obesity via IL-1R1 on CX3CR1(+) cells
Induction of the inflammasome protein cryopyrin (NLRP3) in visceral adipose tissue (VAT) promotes release of the proinflammatory cytokine IL-1β in obesity. Although this mechanism contributes to peripheral metabolic dysfunction, effects on the brain remain unexplored. We investigated whether viscera...
Uloženo v:
| Vydáno v: | J Clin Invest |
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| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Clinical Investigation
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7108893/ https://ncbi.nlm.nih.gov/pubmed/31935195 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI126078 |
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