Structure of an Endosomal Signaling GPCR–G Protein–β-arrestin Mega-Complex

Classically, G protein-coupled receptors (GPCRs) are thought to activate G protein from the plasma membrane and are subsequently desensitized by β-arrestin (βarr). However, some GPCRs continue to signal through G protein from internalized compartments, mediated by a GPCR–G protein–βarr ’megaplex’. N...

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Udgivet i:Nat Struct Mol Biol
Main Authors: Nguyen, Anthony H., Thomsen, Alex R. B., Cahill, Thomas J., Huang, Rick, Huang, Li-Yin, Marcink, Tara, Clarke, Oliver B., Heissel, Søren, Masoudi, Ali, Ben-Hail, Danya, Samaan, Fadi, Dandey, Venkata P., Tan, Yong Zi, Hong, Chuan, Mahoney, Jacob P., Triest, Sarah, Little, John, Chen, Xin, Sunahara, Roger, Steyaert, Jan, Molina, Henrik, Yu, Zhiheng, des Georges, Amedee, Lefkowitz, Robert J.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7108872/
https://ncbi.nlm.nih.gov/pubmed/31740855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-019-0330-y
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