The Glycoprotein of the Live-Attenuated Junin Virus Vaccine Strain Induces Endoplasmic Reticulum Stress and Forms Aggregates prior to Degradation in the Lysosome

Argentine hemorrhagic fever is a potentially lethal disease that is caused by Junin virus (JUNV). There are currently around 5 million individuals at risk of infection within regions of endemicity in Argentina. The live attenuated vaccine strain Candid #1 (Can) is approved for use in regions of ende...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Manning, John T., Yun, Nadya E., Seregin, Alexey V., Koma, Takaaki, Sattler, Rachel A., Ezeomah, Chiomah, Huang, Cheng, de la Torre, Juan C., Paessler, Slobodan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7108856/
https://ncbi.nlm.nih.gov/pubmed/31996435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01693-19
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