A Substitution in the Transmembrane Region of the Glycoprotein Leads to an Unstable Attenuation of Machupo Virus

Machupo virus (MACV) is the etiologic agent of Bolivian hemorrhagic fever (BHF). Utilizing a reverse-genetics system recently developed, we report the rescue of a rationally modified recombinant MACV containing a single mutation in the transmembrane region of the glycoprotein. Following challenge of...

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Detalhes bibliográficos
Main Authors: Patterson, Michael, Koma, Takaaki, Seregin, Alexey, Huang, Cheng, Miller, Milagros, Smith, Jennifer, Yun, Nadezhda, Smith, Jeanon, Paessler, Slobodan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178861/
https://ncbi.nlm.nih.gov/pubmed/25031335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01007-14
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