The Ectodomain of Glycoprotein from the Candid#1 Vaccine Strain of Junin Virus Rendered Machupo Virus Partially Attenuated in Mice Lacking IFN-αβ/γ Receptor

Machupo virus (MACV), a New World arenavirus, is the etiological agent of Bolivian hemorrhagic fever (BHF). Junin virus (JUNV), a close relative, causes Argentine hemorrhagic fever (AHF). Previously, we reported that a recombinant, chimeric MACV (rMACV/Cd#1-GPC) expressing glycoprotein from the Cand...

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Publicado en:PLoS Negl Trop Dis
Autores principales: Koma, Takaaki, Huang, Cheng, Aronson, Judith F., Walker, Aida G., Miller, Milagros, Smith, Jeanon N., Patterson, Michael, Paessler, Slobodan
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2016
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006991/
https://ncbi.nlm.nih.gov/pubmed/27580122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004969
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