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B(C(6)F(5))(3)-Catalyzed α-Deuteration of Bioactive Carbonyl Compounds with D(2)O
An efficient deuteration process of α-C–H bonds in various carbonyl-based pharmaceutical compounds has been developed. Catalytic reactions are initiated by the action of Lewis acidic B(C(6)F(5))(3) and D(2)O, converting a drug molecule into the corresponding boron–enolate. Ensuing deuteration of the...
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| Publicado no: | Adv Synth Catal |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7108789/ https://ncbi.nlm.nih.gov/pubmed/32256276 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adsc.201901419 |
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