Photoredox-catalyzed deuteration and tritiation of pharmaceutical compounds

Deuterium- and tritium-labeled pharmaceutical compounds are pivotal diagnostic tools in drug discovery research, providing vital information about the biological fate of drugs and drug metabolites. Herein we demonstrate that a photoredox-mediated hydrogen atom transfer protocol can efficiently and s...

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Udgivet i:Science
Main Authors: Loh, Yong Yao, Nagao, Kazunori, Hoover, Andrew J., Hesk, David, Rivera, Nelo R., Colletti, Steven L., Davies, Ian W., MacMillan, David W. C.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5907472/
https://ncbi.nlm.nih.gov/pubmed/29123019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aap9674
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