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Photoredox-catalyzed deuteration and tritiation of pharmaceutical compounds
Deuterium- and tritium-labeled pharmaceutical compounds are pivotal diagnostic tools in drug discovery research, providing vital information about the biological fate of drugs and drug metabolites. Herein we demonstrate that a photoredox-mediated hydrogen atom transfer protocol can efficiently and s...
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| Publicado no: | Science |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5907472/ https://ncbi.nlm.nih.gov/pubmed/29123019 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aap9674 |
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