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Trifluoromethylation of arenes and heteroarenes by means of photoredox catalysis

Modern drug discovery relies on the continual development of synthetic methodology to address the many challenges associated with the design of new pharmaceutical agents(1). One such challenge arises from the enzymatic metabolism of drugs in vivo by cytochrome P450 oxidases, which use single-electro...

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Detalhes bibliográficos
Main Authors: Nagib, David A., MacMillan, David W. C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310175/
https://ncbi.nlm.nih.gov/pubmed/22158245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10647
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