PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway

BACKGROUND: Glucocorticoid (GC)-associated osteonecrosis of the femoral head (ONFH) is the most common in non-traumatic ONFH. Despite a strong relationship between GC and ONFH, the detailed mechanisms have remained elusive. Recent studies have shown that GC could directly injure the blood vessels an...

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Vydáno v:Stem Cell Res Ther
Hlavní autoři: Yao, Xudong, Yu, Shengnan, Jing, Xingzhi, Guo, Jiachao, Sun, Kai, Guo, Fengjing, Ye, Yaping
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7106818/
https://ncbi.nlm.nih.gov/pubmed/32228695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-020-01658-y
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