PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway

BACKGROUND: Glucocorticoid (GC)-associated osteonecrosis of the femoral head (ONFH) is the most common in non-traumatic ONFH. Despite a strong relationship between GC and ONFH, the detailed mechanisms have remained elusive. Recent studies have shown that GC could directly injure the blood vessels an...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Stem Cell Res Ther
Main Authors: Yao, Xudong, Yu, Shengnan, Jing, Xingzhi, Guo, Jiachao, Sun, Kai, Guo, Fengjing, Ye, Yaping
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2020
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7106818/
https://ncbi.nlm.nih.gov/pubmed/32228695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-020-01658-y
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares