A Two-hybrid Screen Identifies Cathepsins B and L as Uncoating Factors for Adeno-associated Virus 2 and 8

Vectors based on different serotypes of adeno-associated virus hold great promise for human gene therapy, based on their unique tissue tropisms and distinct immunological profiles. A particularly interesting candidate is AAV8, which can efficiently and rapidly transduce a wide range of tissues in vi...

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Bibliographic Details
Published in:Mol Ther
Main Authors: Akache, Bassel, Grimm, Dirk, Shen, Xuan, Fuess, Sally, Yant, Stephen R, Glazer, Dariya S, Park, Julie, Kay, Mark A
Format: Artigo
Language:Inglês
Published: The American Society of Gene Therapy. Published by Elsevier Inc. 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7106033/
https://ncbi.nlm.nih.gov/pubmed/17235311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.mt.6300053
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