Unrestricted Hepatocyte Transduction with Adeno-Associated Virus Serotype 8 Vectors in Mice

Recombinant adeno-associated virus (rAAV) vectors can mediate long-term stable transduction in various target tissues. However, with rAAV serotype 2 (rAAV2) vectors, liver transduction is confined to only a small portion of hepatocytes even after administration of extremely high vector doses. In ord...

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Main Authors: Nakai, Hiroyuki, Fuess, Sally, Storm, Theresa A., Muramatsu, Shin-ichi, Nara, Yuko, Kay, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2005
Assuntos:
Gene Therapy
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC538708/
https://ncbi.nlm.nih.gov/pubmed/15596817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.1.214-224.2005
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