Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas

Diffuse intrinsic pontine gliomas (DIPGs) are aggressive pediatric brain tumors for which there is currently no effective treatment. Some of these tumors combine gain-of-function mutations in ACVR1, PIK3CA, and histone H3-encoding genes. The oncogenic mechanisms of action of ACVR1 mutations are curr...

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Gepubliceerd in:Cancer Cell
Hoofdauteurs: Fortin, Jerome, Tian, Ruxiao, Zarrabi, Ida, Hill, Graham, Williams, Eleanor, Sanchez-Duffhues, Gonzalo, Thorikay, Midory, Ramachandran, Parameswaran, Siddaway, Robert, Wong, Jong Fu, Wu, Annette, Apuzzo, Lorraine N., Haight, Jillian, You-Ten, Annick, Snow, Bryan E., Wakeham, Andrew, Goldhamer, David J., Schramek, Daniel, Bullock, Alex N., Dijke, Peter ten, Hawkins, Cynthia, Mak, Tak W.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cell Press 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7105820/
https://ncbi.nlm.nih.gov/pubmed/32142668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2020.02.002
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