Crystal structures of REF6 and its complex with DNA reveal diverse recognition mechanisms

Relative of Early Flowing 6 (REF6) is a DNA-sequence-specific H3K27me3/2 demethylase that contains four zinc finger (ZnF) domains and targets several thousand genes in Arabidopsis thaliana. The ZnF domains are essential for binding target genes, but the structural basis remains unclear. Here, we det...

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Bibliografiske detaljer
Udgivet i:	Cell Discov
Main Authors:	Tian, Zizi, Li, Xiaorong, Li, Min, Wu, Wei, Zhang, Manfeng, Tang, Chenjun, Li, Zhihui, Liu, Yunlong, Chen, Zhenhang, Yang, Meiting, Ma, Lulu, Caba, Cody, Tong, Yufeng, Lam, Hon-Ming, Dai, Shaodong, Chen, Zhongzhou
Format:	Artigo
Sprog:	Inglês
Udgivet:	Springer Singapore 2020
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC7105484/ https://ncbi.nlm.nih.gov/pubmed/32257379 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41421-020-0150-6
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Crystal structures of REF6 and its complex with DNA reveal diverse recognition mechanisms

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