Crystal Structures of the Human RNA Demethylase Alkbh5 Reveal Basis for Substrate Recognition

N(6)-Methylation of adenosine is the most ubiquitous and abundant modification of nucleoside in eukaryotic mRNA and long non-coding RNA. This modification plays an essential role in the regulation of mRNA translation and RNA metabolism. Recently, human AlkB homolog 5 (Alkbh5) and fat mass- and obesi...

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Bibliographic Details
Main Authors: Feng, Chong, Liu, Yang, Wang, Guoqiang, Deng, Zengqin, Zhang, Qi, Wu, Wei, Tong, Yufeng, Cheng, Changmei, Chen, Zhongzhou
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002068/
https://ncbi.nlm.nih.gov/pubmed/24616105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.546168
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