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Structures of Human ALKBH5 Demethylase Reveal a Unique Binding Mode for Specific Single-stranded N(6)-Methyladenosine RNA Demethylation
N(6)-Methyladenosine (m(6)A) is the most prevalent internal RNA modification in eukaryotes. ALKBH5 belongs to the AlkB family of dioxygenases and has been shown to specifically demethylate m(6)A in single-stranded RNA. Here we report crystal structures of ALKBH5 in the presence of either its cofacto...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4067165/ https://ncbi.nlm.nih.gov/pubmed/24778178 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.550350 |
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