Structure of human RNA N(6)-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation

ALKBH5 is a 2-oxoglutarate (2OG) and ferrous iron-dependent nucleic acid oxygenase (NAOX) that catalyzes the demethylation of N(6)-methyladenine in RNA. ALKBH5 is upregulated under hypoxia and plays a role in spermatogenesis. We describe a crystal structure of human ALKBH5 (residues 66–292) to 2.0 Å...

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Autors principals: Aik, WeiShen, Scotti, John S., Choi, Hwanho, Gong, Lingzhi, Demetriades, Marina, Schofield, Christopher J., McDonough, Michael A.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2014
Matèries:
Structural Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985658/
https://ncbi.nlm.nih.gov/pubmed/24489119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku085
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