Crystal structures of REF6 and its complex with DNA reveal diverse recognition mechanisms

Relative of Early Flowing 6 (REF6) is a DNA-sequence-specific H3K27me3/2 demethylase that contains four zinc finger (ZnF) domains and targets several thousand genes in Arabidopsis thaliana. The ZnF domains are essential for binding target genes, but the structural basis remains unclear. Here, we det...

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Detalhes bibliográficos
Publicado no:Cell Discov
Main Authors: Tian, Zizi, Li, Xiaorong, Li, Min, Wu, Wei, Zhang, Manfeng, Tang, Chenjun, Li, Zhihui, Liu, Yunlong, Chen, Zhenhang, Yang, Meiting, Ma, Lulu, Caba, Cody, Tong, Yufeng, Lam, Hon-Ming, Dai, Shaodong, Chen, Zhongzhou
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Singapore 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7105484/
https://ncbi.nlm.nih.gov/pubmed/32257379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41421-020-0150-6
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