Dying tumor cell-derived exosomal miR-194-5p potentiates survival and repopulation of tumor repopulating cells upon radiotherapy in pancreatic cancer

BACKGROUND: Tumor repopulation is a major cause of radiotherapy failure. Previous investigations highlighted that dying tumor cells played vital roles in tumor repopulation through promoting proliferation of the residual tumor repopulating cells (TRCs). However, TRCs also suffer DNA damage after rad...

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Publicat a:Mol Cancer
Autors principals: Jiang, Ming-jie, Chen, Yi-yun, Dai, Juan-juan, Gu, Dian-na, Mei, Zhu, Liu, Fu-rao, Huang, Qian, Tian, Ling
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7104536/
https://ncbi.nlm.nih.gov/pubmed/32228703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-020-01178-6
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