Dying tumor cell-derived exosomal miR-194-5p potentiates survival and repopulation of tumor repopulating cells upon radiotherapy in pancreatic cancer

BACKGROUND: Tumor repopulation is a major cause of radiotherapy failure. Previous investigations highlighted that dying tumor cells played vital roles in tumor repopulation through promoting proliferation of the residual tumor repopulating cells (TRCs). However, TRCs also suffer DNA damage after rad...

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Foilsithe in:Mol Cancer
Main Authors: Jiang, Ming-jie, Chen, Yi-yun, Dai, Juan-juan, Gu, Dian-na, Mei, Zhu, Liu, Fu-rao, Huang, Qian, Tian, Ling
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2020
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7104536/
https://ncbi.nlm.nih.gov/pubmed/32228703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-020-01178-6
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