Dying tumor cell-derived exosomal miR-194-5p potentiates survival and repopulation of tumor repopulating cells upon radiotherapy in pancreatic cancer

BACKGROUND: Tumor repopulation is a major cause of radiotherapy failure. Previous investigations highlighted that dying tumor cells played vital roles in tumor repopulation through promoting proliferation of the residual tumor repopulating cells (TRCs). However, TRCs also suffer DNA damage after rad...

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Bibliografische gegevens
Gepubliceerd in:Mol Cancer
Hoofdauteurs: Jiang, Ming-jie, Chen, Yi-yun, Dai, Juan-juan, Gu, Dian-na, Mei, Zhu, Liu, Fu-rao, Huang, Qian, Tian, Ling
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2020
Onderwerpen:
Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7104536/
https://ncbi.nlm.nih.gov/pubmed/32228703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-020-01178-6
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