Identification of the Antidepressant Vilazodone as an Inhibitor of Inositol Polyphosphate Multikinase by Structure-Based Drug Repositioning

Inositol polyphosphate multikinase (IPMK) is required for the biosynthesis of inositol phosphates (IPs) through the phosphorylation of multiple IP metabolites such as IP3 and IP4. The biological significance of IPMK’s catalytic actions to regulate cellular signaling events such as growth and metabol...

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Detalhes bibliográficos
Publicado no:Mol Cells
Main Authors: Lee, Boah, Park, Seung Ju, Lee, Seulgi, Park, Seung Eun, Lee, Eunhye, Song, Ji-Joon, Byun, Youngjoo, Kim, Seyun
Formato: Artigo
Idioma:Inglês
Publicado em: Korean Society for Molecular and Cellular Biology 2020
Assuntos:
Rapid Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7103885/
https://ncbi.nlm.nih.gov/pubmed/32209735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14348/molcells.2020.0051
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