Identification of the Antidepressant Vilazodone as an Inhibitor of Inositol Polyphosphate Multikinase by Structure-Based Drug Repositioning

Inositol polyphosphate multikinase (IPMK) is required for the biosynthesis of inositol phosphates (IPs) through the phosphorylation of multiple IP metabolites such as IP3 and IP4. The biological significance of IPMK’s catalytic actions to regulate cellular signaling events such as growth and metabol...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cells
Prif Awduron: Lee, Boah, Park, Seung Ju, Lee, Seulgi, Park, Seung Eun, Lee, Eunhye, Song, Ji-Joon, Byun, Youngjoo, Kim, Seyun
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Korean Society for Molecular and Cellular Biology 2020
Pynciau:
Rapid Report
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7103885/
https://ncbi.nlm.nih.gov/pubmed/32209735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14348/molcells.2020.0051
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