Identification of the Antidepressant Vilazodone as an Inhibitor of Inositol Polyphosphate Multikinase by Structure-Based Drug Repositioning

Inositol polyphosphate multikinase (IPMK) is required for the biosynthesis of inositol phosphates (IPs) through the phosphorylation of multiple IP metabolites such as IP3 and IP4. The biological significance of IPMK’s catalytic actions to regulate cellular signaling events such as growth and metabol...

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Publicado en:Mol Cells
Autores principales: Lee, Boah, Park, Seung Ju, Lee, Seulgi, Park, Seung Eun, Lee, Eunhye, Song, Ji-Joon, Byun, Youngjoo, Kim, Seyun
Formato: Artigo
Lenguaje:Inglês
Publicado: Korean Society for Molecular and Cellular Biology 2020
Materias:
Rapid Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7103885/
https://ncbi.nlm.nih.gov/pubmed/32209735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14348/molcells.2020.0051
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