Identification of the Antidepressant Vilazodone as an Inhibitor of Inositol Polyphosphate Multikinase by Structure-Based Drug Repositioning

Inositol polyphosphate multikinase (IPMK) is required for the biosynthesis of inositol phosphates (IPs) through the phosphorylation of multiple IP metabolites such as IP3 and IP4. The biological significance of IPMK’s catalytic actions to regulate cellular signaling events such as growth and metabol...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Cells
Hauptverfasser: Lee, Boah, Park, Seung Ju, Lee, Seulgi, Park, Seung Eun, Lee, Eunhye, Song, Ji-Joon, Byun, Youngjoo, Kim, Seyun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Korean Society for Molecular and Cellular Biology 2020
Schlagworte:
Rapid Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7103885/
https://ncbi.nlm.nih.gov/pubmed/32209735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14348/molcells.2020.0051
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