Oncolytic vaccinia virus delivering tethered IL-12 enhances antitumor effects with improved safety

Immune checkpoint blockade is arguably the most effective current cancer therapy approach; however, its efficacy is limited to patients with “hot” tumors, warranting an effective approach to transform “cold” tumors. Oncolytic viruses (especially properly armed ones) have positive effects on almost e...

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Dettagli Bibliografici
Pubblicato in:J Immunother Cancer
Autori principali: Ge, Yan, Wang, Haiyan, Ren, Jinghua, Liu, Weilin, Chen, Lingjuan, Chen, Hongqi, Ye, Junjie, Dai, Enyong, Ma, Congrong, Ju, Songguang, Guo, Zong Sheng, Liu, Zuqiang, Bartlett, David L
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMJ Publishing Group 2020
Soggetti:
Short Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7103801/
https://ncbi.nlm.nih.gov/pubmed/32209602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-000710
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