Exo1 phosphorylation inhibits exonuclease activity and prevents fork collapse in rad53 mutants independently of the 14-3-3 proteins

The S phase checkpoint is crucial to maintain genome stability under conditions that threaten DNA replication. One of its critical functions is to prevent Exo1-dependent fork degradation, and Exo1 is phosphorylated in response to different genotoxic agents. Exo1 seemed to be regulated by several pos...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Nucleic Acids Res
Hlavní autoři: Morafraile, Esther C, Bugallo, Alberto, Carreira, Raquel, Fernández, María, Martín-Castellanos, Cristina, Blanco, Miguel G, Segurado, Mónica
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7102976/
https://ncbi.nlm.nih.gov/pubmed/32020204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa054
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky