Exo1 phosphorylation inhibits exonuclease activity and prevents fork collapse in rad53 mutants independently of the 14-3-3 proteins

The S phase checkpoint is crucial to maintain genome stability under conditions that threaten DNA replication. One of its critical functions is to prevent Exo1-dependent fork degradation, and Exo1 is phosphorylated in response to different genotoxic agents. Exo1 seemed to be regulated by several pos...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nucleic Acids Res
Egile Nagusiak: Morafraile, Esther C, Bugallo, Alberto, Carreira, Raquel, Fernández, María, Martín-Castellanos, Cristina, Blanco, Miguel G, Segurado, Mónica
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2020
Gaiak:
Genome Integrity, Repair and Replication
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7102976/
https://ncbi.nlm.nih.gov/pubmed/32020204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa054
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