SIRT6 coordinates with CHD4 to promote chromatin relaxation and DNA repair

Genomic instability is an underlying hallmark of cancer and is closely associated with defects in DNA damage repair (DDR). Chromatin relaxation is a prerequisite for DDR, but how chromatin accessibility is regulated remains elusive. Here we report that the histone deacetylase SIRT6 coordinates with...

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Enregistré dans:
Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Hou, Tianyun, Cao, Ziyang, Zhang, Jun, Tang, Ming, Tian, Yuan, Li, Yinglu, Lu, Xiaopeng, Chen, Yongcan, Wang, Hui, Wei, Fu-Zheng, Wang, Lina, Yang, Yang, Zhao, Ying, Wang, Zimei, Wang, Haiying, Zhu, Wei-Guo
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2020
Sujets:
Genome Integrity, Repair and Replication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7102973/
https://ncbi.nlm.nih.gov/pubmed/31970415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa006
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