SIRT7-mediated ATM deacetylation is essential for its deactivation and DNA damage repair

The activation of ataxia-telangiectasia mutated (ATM) upon DNA damage involves a cascade of reactions, including acetylation by TIP60 and autophosphorylation. However, how ATM is progressively deactivated after completing DNA damage repair remains obscure. Here, we report that sirtuin 7 (SIRT7)–medi...

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Vydáno v:Sci Adv
Hlavní autoři: Tang, Ming, Li, Zhiming, Zhang, Chaohua, Lu, Xiaopeng, Tu, Bo, Cao, Ziyang, Li, Yinglu, Chen, Yongcan, Jiang, Lu, Wang, Hui, Wang, Lina, Wang, Jiadong, Liu, Baohua, Xu, Xingzhi, Wang, Haiying, Zhu, Wei-Guo
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2019
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436926/
https://ncbi.nlm.nih.gov/pubmed/30944854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aav1118
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