Destabilization of linker histone H1.2 is essential for ATM activation and DNA damage repair

Linker histone H1 is a master regulator of higher order chromatin structure, but its involvement in the DNA damage response and repair is unclear. Here, we report that linker histone H1.2 is an essential regulator of ataxia telangiectasia mutated (ATM) activation. We show that H1.2 protects chromati...

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Detalhes bibliográficos
Publicado no:Cell Res
Main Authors: Li, Zhiming, Li, Yinglu, Tang, Ming, Peng, Bin, Lu, Xiaopeng, Yang, Qiaoyan, Zhu, Qian, Hou, Tianyun, Li, Meiting, Liu, Chaohua, Wang, Lina, Xu, Xingzhi, Zhao, Ying, Wang, Haiying, Yang, Yang, Zhu, Wei-Guo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6028381/
https://ncbi.nlm.nih.gov/pubmed/29844578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-018-0048-0
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