p53 cooperates with SIRT6 to regulate cardiolipin de novo biosynthesis

The tumor suppressor p53 has critical roles in regulating lipid metabolism, but whether and how p53 regulates cardiolipin (CL) de novo biosynthesis is unknown. Here, we report that p53 physically interacts with histone deacetylase SIRT6 in vitro and in vivo, and this interaction increases following...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Li, Meiting, Hou, Tianyun, Gao, Tian, Lu, Xiaopeng, Yang, Qiaoyan, Zhu, Qian, Li, Zhiming, Liu, Chaohua, Mu, Guanqun, Liu, Ge, Bao, Yantao, Wen, He, Wang, Lina, Wang, Haiying, Zhao, Ying, Gu, Wei, Yang, Yang, Zhu, Wei-Guo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6148051/
https://ncbi.nlm.nih.gov/pubmed/30237540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0984-0
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