p53 cooperates with SIRT6 to regulate cardiolipin de novo biosynthesis

The tumor suppressor p53 has critical roles in regulating lipid metabolism, but whether and how p53 regulates cardiolipin (CL) de novo biosynthesis is unknown. Here, we report that p53 physically interacts with histone deacetylase SIRT6 in vitro and in vivo, and this interaction increases following...

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Vydáno v:Cell Death Dis
Hlavní autoři: Li, Meiting, Hou, Tianyun, Gao, Tian, Lu, Xiaopeng, Yang, Qiaoyan, Zhu, Qian, Li, Zhiming, Liu, Chaohua, Mu, Guanqun, Liu, Ge, Bao, Yantao, Wen, He, Wang, Lina, Wang, Haiying, Zhao, Ying, Gu, Wei, Yang, Yang, Zhu, Wei-Guo
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6148051/
https://ncbi.nlm.nih.gov/pubmed/30237540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0984-0
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