SIRT6 coordinates with CHD4 to promote chromatin relaxation and DNA repair

Genomic instability is an underlying hallmark of cancer and is closely associated with defects in DNA damage repair (DDR). Chromatin relaxation is a prerequisite for DDR, but how chromatin accessibility is regulated remains elusive. Here we report that the histone deacetylase SIRT6 coordinates with...

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Udgivet i:Nucleic Acids Res
Main Authors: Hou, Tianyun, Cao, Ziyang, Zhang, Jun, Tang, Ming, Tian, Yuan, Li, Yinglu, Lu, Xiaopeng, Chen, Yongcan, Wang, Hui, Wei, Fu-Zheng, Wang, Lina, Yang, Yang, Zhao, Ying, Wang, Zimei, Wang, Haiying, Zhu, Wei-Guo
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7102973/
https://ncbi.nlm.nih.gov/pubmed/31970415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa006
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