SIRT6 coordinates with CHD4 to promote chromatin relaxation and DNA repair

Genomic instability is an underlying hallmark of cancer and is closely associated with defects in DNA damage repair (DDR). Chromatin relaxation is a prerequisite for DDR, but how chromatin accessibility is regulated remains elusive. Here we report that the histone deacetylase SIRT6 coordinates with...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Hou, Tianyun, Cao, Ziyang, Zhang, Jun, Tang, Ming, Tian, Yuan, Li, Yinglu, Lu, Xiaopeng, Chen, Yongcan, Wang, Hui, Wei, Fu-Zheng, Wang, Lina, Yang, Yang, Zhao, Ying, Wang, Zimei, Wang, Haiying, Zhu, Wei-Guo
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7102973/
https://ncbi.nlm.nih.gov/pubmed/31970415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa006
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