SIRT6 coordinates with CHD4 to promote chromatin relaxation and DNA repair

Genomic instability is an underlying hallmark of cancer and is closely associated with defects in DNA damage repair (DDR). Chromatin relaxation is a prerequisite for DDR, but how chromatin accessibility is regulated remains elusive. Here we report that the histone deacetylase SIRT6 coordinates with...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Hou, Tianyun, Cao, Ziyang, Zhang, Jun, Tang, Ming, Tian, Yuan, Li, Yinglu, Lu, Xiaopeng, Chen, Yongcan, Wang, Hui, Wei, Fu-Zheng, Wang, Lina, Yang, Yang, Zhao, Ying, Wang, Zimei, Wang, Haiying, Zhu, Wei-Guo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Genome Integrity, Repair and Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7102973/
https://ncbi.nlm.nih.gov/pubmed/31970415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa006
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