Structural basis of the zinc-induced cytoplasmic aggregation of the RNA-binding protein SFPQ

SFPQ is a ubiquitous nuclear RNA-binding protein implicated in many aspects of RNA biogenesis. Importantly, nuclear depletion and cytoplasmic accumulation of SFPQ has been linked to neuropathological conditions such as Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). Here, we d...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Huang, Jie, Ringuet, Mitchell, Whitten, Andrew E, Caria, Sofia, Lim, Yee Wa, Badhan, Rahul, Anggono, Victor, Lee, Mihwa
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
Matèries:
Structural Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7102971/
https://ncbi.nlm.nih.gov/pubmed/32034402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa076
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