Structural basis of the zinc-induced cytoplasmic aggregation of the RNA-binding protein SFPQ

SFPQ is a ubiquitous nuclear RNA-binding protein implicated in many aspects of RNA biogenesis. Importantly, nuclear depletion and cytoplasmic accumulation of SFPQ has been linked to neuropathological conditions such as Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). Here, we d...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Huang, Jie, Ringuet, Mitchell, Whitten, Andrew E, Caria, Sofia, Lim, Yee Wa, Badhan, Rahul, Anggono, Victor, Lee, Mihwa
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7102971/
https://ncbi.nlm.nih.gov/pubmed/32034402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa076
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