Structural basis of the zinc-induced cytoplasmic aggregation of the RNA-binding protein SFPQ

SFPQ is a ubiquitous nuclear RNA-binding protein implicated in many aspects of RNA biogenesis. Importantly, nuclear depletion and cytoplasmic accumulation of SFPQ has been linked to neuropathological conditions such as Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). Here, we d...

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Bibliografski detalji
Izdano u:Nucleic Acids Res
Glavni autori: Huang, Jie, Ringuet, Mitchell, Whitten, Andrew E, Caria, Sofia, Lim, Yee Wa, Badhan, Rahul, Anggono, Victor, Lee, Mihwa
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Structural Biology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7102971/
https://ncbi.nlm.nih.gov/pubmed/32034402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa076
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