Alteration of CTCF-associated chromatin neighborhood inhibits TAL1-driven oncogenic transcription program and leukemogenesis

Aberrant activation of the TAL1 is associated with up to 60% of T-ALL cases and is involved in CTCF-mediated genome organization within the TAL1 locus, suggesting that CTCF boundary plays a pathogenic role in T-ALL. Here, we show that −31-Kb CTCF binding site (−31CBS) serves as chromatin boundary th...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nucleic Acids Res
Prif Awduron: Li, Ying, Liao, Ziwei, Luo, Huacheng, Benyoucef, Aissa, Kang, Yuanyuan, Lai, Qian, Dovat, Sinisa, Miller, Barbara, Chepelev, Iouri, Li, Yangqiu, Zhao, Keji, Brand, Marjorie, Huang, Suming
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2020
Pynciau:
Molecular Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7102946/
https://ncbi.nlm.nih.gov/pubmed/32086528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa098
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