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Positioning heterochromatin at the nuclear periphery suppresses histone turnover to promote epigenetic inheritance
In eukaryotes, heterochromatin is generally located at the nuclear periphery. This study investigates the biological significance of perinuclear positioning for heterochromatin maintenance and gene silencing. We identify the nuclear rim protein Amo1(NUPL2) as a factor required for the propagation of...
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| Udgivet i: | Cell |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7102895/ https://ncbi.nlm.nih.gov/pubmed/31883795 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.12.004 |
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