CPF Recruitment to Non-canonical Transcription Termination Sites Triggers Heterochromatin Assembly and Gene Silencing

In eukaryotic genomes, heterochromatin is targeted by RNAi machinery and/or by pathways requiring RNA elimination and transcription termination factors. However, a direct connection between termination machinery and RNA polymerase II (RNAPII) transcriptional activity at heterochromatic loci has rema...

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Publicat a:Cell Rep
Autors principals: Vo, Tommy V., Dhakshnamoorthy, Jothy, Larkin, Madeline, Zofall, Martin, Thillainadesan, Gobi, Balachandran, Vanivilasini, Holla, Sahana, Wheeler, David, Grewal, Shiv I.S.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7457318/
https://ncbi.nlm.nih.gov/pubmed/31269446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.05.107
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