Positioning heterochromatin at the nuclear periphery suppresses histone turnover to promote epigenetic inheritance

In eukaryotes, heterochromatin is generally located at the nuclear periphery. This study investigates the biological significance of perinuclear positioning for heterochromatin maintenance and gene silencing. We identify the nuclear rim protein Amo1(NUPL2) as a factor required for the propagation of...

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Vydáno v:Cell
Hlavní autoři: Holla, Sahana, Dhakshnamoorthy, Jothy, Folco, H. Diego, Balachandran, Vanivilasini, Xiao, Hua, Sun, Ling-ling, Wheeler, David, Zofall, Martin, Grewal, Shiv I. S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7102895/
https://ncbi.nlm.nih.gov/pubmed/31883795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.12.004
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