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Trimethoprim and other nonclassical antifolates an excellent template for searching modifications of dihydrofolate reductase enzyme inhibitors

The development of new mechanisms of resistance among pathogens, the occurrence and transmission of genes responsible for antibiotic insensitivity, as well as cancer diseases have been a serious clinical problem around the world for over 50 years. Therefore, intense searching of new leading structur...

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Detalhes bibliográficos
Publicado no:J Antibiot (Tokyo)
Main Authors: Wróbel, Agnieszka, Arciszewska, Karolina, Maliszewski, Dawid, Drozdowska, Danuta
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7102388/
https://ncbi.nlm.nih.gov/pubmed/31578455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41429-019-0240-6
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