Adar RNA editing-dependent and -independent effects are required for brain and innate immune functions in Drosophila

ADAR RNA editing enzymes are high-affinity dsRNA-binding proteins that deaminate adenosines to inosines in pre-mRNA hairpins and also exert editing-independent effects. We generated a Drosophila Adar(E374A) mutant strain encoding a catalytically inactive Adar with CRISPR/Cas9. We demonstrate that Ad...

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發表在:Nat Commun
Main Authors: Deng, Patricia, Khan, Anzer, Jacobson, Dionna, Sambrani, Nagraj, McGurk, Leeanne, Li, Xianghua, Jayasree, Aswathy, Hejatko, Jan, Shohat-Ophir, Galit, O’Connell, Mary A., Li, Jin Billy, Keegan, Liam P.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2020
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7101428/
https://ncbi.nlm.nih.gov/pubmed/32221286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15435-1
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